Innovations that improve & extend patients’ lives
"The technology being developed at Pulse has the potential to quickly, safely, painlessly and effectively remove skin lesions, including cancers, for both clinical and cosmetic purposes. It is tremendously exciting. We will be hugely proud to bring it to the public."
Bob Duggan
Pulse Biosciences is a bioelectric medicine company, developing innovations that improve and extend patients’ lives. Pulse’s groundbreaking Nano-Pulse Stimulation (NPS) technology is used to treat a variety of conditions that currently have no established optimal solution. The first planned commercial product, the CellFX System, uses NPS technology to address a range of dermatologic conditions.
NPS technology is based on nanosecond pulses of high-amplitude electrical energy that non-thermally clear targeted cells while sparing adjacent non-cellular tissue. It is a precise, drug‐free tissue treatment that directly affects cell membranes and intracellular structures to stimulate unique behavior in the cells. It initiates a regulated cell death process with minimal inflammatory response, thus improving healing outcomes. It supports the replacement of treated tissue cells with healthy tissue cells.
In cancerous lesions, NPS has been shown to induce immunogenic cell death (ICD), exposing the antigens of the treated cells to the immune system. A result is the generation of cytotoxic T cells and the mounting of an adaptive immune response targeted against those cells.
Pulse Biosciences is investigating a variety of applications for its technology, including immuno‐oncology, dermatology, and veterinary medicine.
Nano-Pulse Stimulation (NPS™) is a proprietary technology that delivers nanosecond pulses of high-amplitude electrical energy to non-thermally clear targeted cells while sparing adjacent non-cellular tissue.
These ultrafast electrical energy pulses have pulse durations from billionths up to a millionth of a second.
When applied to the targeted tissue, NPS energy pulses enter cells and alter the function of the internal cellular organelles, including the mitochondria and endoplasmic reticulum, without disrupting extracellular tissue. This leads to regulated cell death (RCD), a process exhibited by cells in the human body when they undergo stress and are unable to restore cellular homeostasis.
The CellFX System delivers pulses that directly affect the internal organelles of targeted cells but have no functional effect on non-cellular tissue, such as collagen (a proteinaceous tissue that forms the structural foundation of the skin). In short, it delivers a unique cell-focused effect to the internal structures of treated cells while preserving surrounding non-cellular tissue. This combination may lead to highly differentiated treatment applications.
The CellFX™ System is planned as a commercial product using NPS technology to create a non-toxic and non-thermal biophysical disruption of targeted cells, using tunable speed and amplitude of NPS pulses.
“Along with a team of qualified scientists, we have studied Pulse Biosciences’ core technology, the strength of leadership and management, patent portfolio, breadth of engineering and research talent, as well as our perceived long‐term sense of the robust potential of NPS technology in healthcare. We are impressed by what we have seen and with the experience, ability, and enthusiasm of the Pulse Biosciences team. We have previously worked closely with several members of the Pulse Biosciences management team, including Darrin Uecker, President, and CEO, and Dave Danitz and Edison Manuel, engineering and operations executives. Each of them were critical to our previous success at Computer Motion, Inc. (now part of Intuitive Surgical, Inc.) in launching computer-assisted robotics in the field of human surgery. We look forward to working with the Pulse Biosciences team on this important technology that we believe can impact healthcare in a meaningful and sustainable manner for the significant betterment of all,” Mr. Duggan and Dr. Zanganeh in a joint statement.
Presentation of clinical studies data to clear skin lesions at ASDS annual meeting
17 Oct 2019
Go to linkPromising non-thermal treatment for skin conditions
18 Sep 2019
Go to linkPulse Biosciences CellFX™ system to be given podium presentation at major Aesthetic Procedures conference
06 Aug 2019
Go to linkPublication of dose-response study using PulseX system
02 Aug 2019
Go to linkResearch program explores energy for lesion treatment
14 May 2019
Go to linkPresentations announced at 2019 American Society for Laser Medicine and Surgery annual conference
26 Mar 2019
Go to link510(K) for CellFX™ submitted to FDA
28 Jan 2019
Go to linkPositive clinical results of Nano-Pulse Stimulation to treat patients with Sebaceous Hyperplasia Lesions on the face
07 Jan 2019
Go to linkContinued expansion of its clinical study programs in dermatology
11 Oct 2018
Go to linkTreats initial patient in its human study evaluating the effects of Nano-Pulse Stimulation in Basal Cell Carcinoma
30 Jul 2018
Go to linkODU researchers are using electric pulses to kill cancer cells. And they say it’s working.
27 Jun 2018
Go to linkPositive results from its first study evaluating a clinical target at major scientific meeting
12 Apr 2018
Go to linkBob Duggan has been appointed Chairman of the Board; Ken Clark, Dr. Thomas Fogarty and Manmeet S. Soni have been appointed as independent directors
02 Nov 2017
Go to linkPulse Biosciences announces $30 million private placement
23 Sep 2017
Go to linkWithdrawal and resubmission of 510(K) application for PulseTx™ System
11 Sep 2017
Go to linkTreatment of first patient in study to evaluate Novel Nano-Pulse Stimulation for Seborrheic Keratosis Lesions
06 Jun 2017
Go to linkPulse Biosciences submits 510(K)Application to FDA for PULSEX™ system
14 Mar 2017
Go to linkBob Duggan and Dr. Maky Zanganeh acquire combined interest of 17.1% of Pulse Biosciences
09 Feb 2017
Go to linkEmerging technology: a look at nano-pulse stimulation
19 Aug 2020
Go to linkNano-pulse stimulation technology produces favorable results in several clinical studies presented at the 2020 ASLMS virtual annual conference
09 Jul 2020
Go to linkPulse Biosciences, Inc.’s nano-pulse stimulation technology produces favorable results for warts and all
07 Jul 2020
Go to linkHigh amplitude electromagnetic fields: a new player in dermatology
06 Jul 2020
Go to linkNew device treats nonmelanoma skin cancer
04 Jun 2020
Go to linkPulse plans to seek $30m from investors
07 Apr 2020
Go to linkDecrease in the number of active acne lesions on the back 3 months after a single nano-pulse stimulation treatment —Mark S. Nestor, MD, PhD
25 Oct 2019
Go to linkThis first human study of the treatment describes the use of nanosecond pulsed electric fields (nsPEF) on the skin
18 Sep 2019
Go to linkNano-pulse stimulation represents novel technology for delivering cellular specific therapy that is being investigated for its potential to treat both benign and malignant dermatological lesions
14 May 2019
Go to link"This is an incredibly exciting technology...There’s a whole world, both cosmetic and clinical, including skin cancer that’s going to be looked at continually as we go forward."
Mark S. Nestor
MD, PhD
Presentation of clinical studies data to clear skin lesions at ASDS annual meeting
17 Oct 2019
Promising non-thermal treatment for skin conditions
18 Sep 2019
Pulse Biosciences CellFX™ system to be given podium presentation at major Aesthetic Procedures conference
06 Aug 2019
Publication of dose-response study using PulseX system
02 Aug 2019
Research program explores energy for lesion treatment
14 May 2019
Presentations announced at 2019 American Society for Laser Medicine and Surgery annual conference
26 Mar 2019
510(K) for CellFX™ submitted to FDA
28 Jan 2019
Positive clinical results of Nano-Pulse Stimulation to treat patients with Sebaceous Hyperplasia Lesions on the face
07 Jan 2019
Continued expansion of its clinical study programs in dermatology
11 Oct 2018
Treats initial patient in its human study evaluating the effects of Nano-Pulse Stimulation in Basal Cell Carcinoma
30 Jul 2018
ODU researchers are using electric pulses to kill cancer cells. And they say it’s working.
27 Jun 2018
Positive results from its first study evaluating a clinical target at major scientific meeting
12 Apr 2018
Bob Duggan has been appointed Chairman of the Board; Ken Clark, Dr. Thomas Fogarty and Manmeet S. Soni have been appointed as independent directors
02 Nov 2017
Pulse Biosciences announces $30 million private placement
23 Sep 2017
Withdrawal and resubmission of 510(K) application for PulseTx™ System
11 Sep 2017
Treatment of first patient in study to evaluate Novel Nano-Pulse Stimulation for Seborrheic Keratosis Lesions
06 Jun 2017
Pulse Biosciences submits 510(K)Application to FDA for PULSEX™ system
14 Mar 2017
Bob Duggan and Dr. Maky Zanganeh acquire combined interest of 17.1% of Pulse Biosciences
09 Feb 2017
Emerging technology: a look at nano-pulse stimulation
19 Aug 2020
Nano-pulse stimulation technology produces favorable results in several clinical studies presented at the 2020 ASLMS virtual annual conference
09 Jul 2020
Pulse Biosciences, Inc.’s nano-pulse stimulation technology produces favorable results for warts and all
07 Jul 2020
High amplitude electromagnetic fields: a new player in dermatology
06 Jul 2020
New device treats nonmelanoma skin cancer
04 Jun 2020
Pulse plans to seek $30m from investors
07 Apr 2020
Decrease in the number of active acne lesions on the back 3 months after a single nano-pulse stimulation treatment —Mark S. Nestor, MD, PhD
25 Oct 2019
This first human study of the treatment describes the use of nanosecond pulsed electric fields (nsPEF) on the skin
18 Sep 2019
Nano-pulse stimulation represents novel technology for delivering cellular specific therapy that is being investigated for its potential to treat both benign and malignant dermatological lesions
14 May 2019
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